I've had enough splash wounds over the years with the 22cal. Vmax, that I have stopped using them, except in my son's 223wssm, where we use the 60gr Vmax at 3,700fps. It is scary accurate, and hits hard enough we don't get spinners or runners. Instead, once in awhile, we get one to stand back up, but they don't go anywhere.
In my 243, the 75gr Vmax has been stellar, from 20yds out to a bit over 400yds. The first 33-34 coyotes I shot with that load had no exits, no fur damage. The first one with fur damage was, shall we say, extreme. In most cases, this Vmax does not exit.
The opposite happened with the Nosler Btip. In 22cal, they perform great, no splashes. In the 243, the 55gr Btip gave me more runners and floppers than anything else, enough that I stopped using them in the 243.