If you hit a coyote behind the diaphragm or low in the brisket, It may knock him down, then he may get up and haul freight once he has over come some of the shock.
In the mid 80's, we knocked down 6 coyotes that got back up and hobbled off on a three day hunt down in Mexico. We were shooting a Ruger 77 in 22/250 with the speer 52g hp with a load of 35g of IMR 4064. That particular lot# of bullets was made with thin jackets and they were exploding on shoulder blades and on Ribs. Speer has since thickened up the jacket a tad.
I will never get over just how hard a coyote can be to kill, as I have seen some very incredible things happen when coyotes have been hit hard.
One issue that I had when hunting with an AR was that the factory trigger was so hard to pull, that the shooter would often yank the shot which lead to bad hits. This happened frequently, so I installed a $200 trigger.
I am a firm believer that 55's in the 3250 fps area will dump coyotes hard, all sierra lead tips, and the Nosler 55g ballistic tips. Sierra 55g BTHP is a super accurate bullet and is tougher than the lead tip bullets, and we did not have trouble with that bullet either.
Quartering shots on coyotes either coming or going can be difficult, and running shots are a hail mary to a lot of guys that have trouble aiming off the body leading a coyote on the run.
Good luck