Its hard to say, as a wild animal I think the wolf would disengage if it thought it would take too much damage. Where as the pit which is bred purely to fight would have to be killed to lose. THe strength of the wolf is the pack and the strength of the pack is the wolf. Two or more wolves they would definitely take on a larger dog. But they , like coyotes, knownothing of sport fighting or bravery or anything else. Its not bred into them, they are about efficiency and food. THe wolf being much larger probably could kill the dog, but I doubt it would fight to the point it could. 1 on 1.