Hopefully the dust has settled....
After reading through most of this and taking advise of some that have rolled their own long before I was born, I managed to take a little different approach.
First and foremost - Prep work. Close is not good enough. I want everything to be as identical as I can get it. Brass trim, champering,...
I run a series of loads starting about 2.0 under max (pending cart. size/bullet weight,...at .5 gr incriments with a seating depth about .025 off the lands.
Shoot my series of tests until I get a load that gives me a decent group.
Retest that load
If I repeat the group, then I use that charge to work on my seating depth. Given that the longer oal will work in my firearm, I start at .005 off the lands and work away at steps of .005.
When I get my best group, I retest that load/depth
If I repeat the group, I tweak the charge up and down to see if I am gaining concentration or falling apart.
If I am not satisfied, I'll tweak the seating depth up and down by .002 that final charge
In some cases, like a load I was working for my Browning .270, it just didn't come all the way together - I changed powders and started all over.
Ultimately, I chronoy my load and see what it is really doing. In some cases I'm pleasantly surprised that I'm a bit faster than expected; or slower. If I'm considerably slower than what thwat charge should be, I'll look for different brass, primer or even powder.
Maybe not the right way, but it works well for me!