+1 Dave
Often a VLD design does not lend well to accuracy, take the 55g Sierra spt, the 55g Sierra bthp, and the 55 and 63g sierra semi points. As your leade gets shot out, or you have a rifle with a long leade in it, then the semi point bullets will very often shoot like a Berger match bullet.
I have had some fantastic luck for a hunting bullet in the sierra 55g BTHP, which is a tough bullet and excellent for bone breaking shots and quartering shots in a 223 to 22/250 AI.
Like DAA, I think of a bullets killing and penetrating ability first. When we hunted in Mexico, we killed a tremendous number of coyotes on a single trip. We would experiment with various bullets, shooting at least 20 animals straight with each bullet, amazing how you can get poor bullet performance at times at certain angles and distances. We learned to like a tougher bullet, and the Nosler 55g Ballistic tip fit the tougher bullet description nicely, and all the sierra 55's(blitz king was not out then). If you want to make a real mess out of a coyote, shoot him with a Sierra 55g Sierra lead tip blitz at 3500 fps...holy cow.
Sierra 55g BTSP is a great bullet, but often a barrel will not like a boat tail bullet, thus the 55g Sierra spt will shine.
I do not shoot steel, and 300 yards is half way around the world. In my coyote hunting since 1975, the average shots would be between 85-125 yards. We did have a lot of 200-225 yard shots, this was Dessert hunting. 4 times in my life I have had shots from 400-450 yards. Hunting distances will vary in different parts of the country, and you have to adapt. Adapting to your part of the country is what drives the variations in what calibers a guy will want to shoot.