I started shooting rifles back in the late 1940s and started reloading ammo during 1952 year. Over the years I have looked for the perfict varmint rifle round. So far I have used the 17 HM2, 17 HMR, 17 Rem, 204 Ruger, 22LR, 22WMR, 22 Hornet,221 Rem, 222 Rem, 223 Rem, 220 Swift, 243 Win.and 25-06 rifles. I plan on trying out the new Rem 17 Fireball when it comes out. For prairie dog shooting the two would be the 17 HMR and .204 Ruger. For coyotes the 203 Rem and the 220 Swift. For varmints bigger than coyotes the 243 Win.and 25-06 Rem. Any gun nut knows that haveing only two varmint rifles will always let you wondering about the other rounds.