Bozdogkiller I would have to humbly disagree. For example lets say we use the same grain bullet, a 40grn V-Max and a 26" barrel out of both rifles. Both rifles will shoot both bullets at a velocity of 4100fps. However, the 204 40grn bullet has a BC of .275 and the 22-250 .22 cal 40grn bullet has a BC of .200. I think it's pretty obvious which rifle will shoot flatter, it's the 204 hands down. Even if the 22-250 moves up to a 50grn V-Max, that bullet has a BC of .242, so even the heavier .22 cal 50grn bullet still has less BC than the 204 20 cal 40grn Bullet.
The bottom line, the 204, using the 40grn V-max will out shoot and shoot flatter than the 22-250 using either the 40grn, 50 or 55grn .22 cal bullets.
Now it gets more complicated when you start comparing the endless combinations of handloads, powders, primers, seating depths, barrel twist, etc etc.... but my above comparison was a simple "apples to apples" comparison.
For the 22-250 to even approach the performance of the .204, it has to be loaded HOT!!! And even then, you will just be burning out your barrels trying to keep up. The .204 doesn't have to be loaded hot to achieve this performance, thus longer barrel life, etc. I know that this is all just ballistics.... i.e. paper information as opposed to actually shooting out in the field.. but I have dropped enough yotes dead in their tracks with the .204 that I know firsthand what it can do. By the way, im not trying to be argumentative, I don't want to come across as a know-it-all that believes that the .204 is the only caliber to own. I just like constructive argument. If you have an argument against mine, I am all ears.. I learn something new every day!