One word of caution on the H-380 powder usage. It is temperature sensitive. I had a scary adventure with this, where a 22-250 load was developed at 50-60 degrees, and then shot at 85 degrees, which resulted in a very stiff bolt lift. I pulled all of my H-380 loads after that. In the interest of full disclosure, this load was near a published max. charge weight. Not over, but near the max.
I warned a fellow shooter, that goes with a bunch of guys, P-dog shooting. He came back with a very similar story on a P-dog shoot, where a fellow shooter, using H-380 loads, had to pound his bolt open! There are too many other good powder choices out there, that are not as temperature sensitive as H-380. If one is well below max., then maybe H-380 would be OK, but I contend the temperature sensitivity will change POI, at a minimum, and probably open groups up, even if the pressure doesn't increase to dangerous levels. YMMV
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