The 53 v-max has a better BC and probably a better choice. My buddy shot a BIG prairie dog this year in SD at 589 yards with a 53 v-max out of his Savage 22-250. Blew a hole about 1 1/2" in that pd. I probably wouldn't have believed it, if I hadn't seen it. I've killed several coyotes with the 53 gr in a .223 with good results, but not with a 22-250.
Keep us posted on how they work.