If you want fur friendly with 22-250 type ballistics, then go with the .204 Ruger. It shoots very flat, low wind drift, and still carries enough down-range energy to cleanly kill a coyote. There are quite a few good factory offerings out there, and if you are a reloader, or know someone who can reload for you, the 35gr Berger bullet is reported to be very fur friendly. I have shot many coyotes with a 22-250 and if you want to save the hides, you had better learn how to sew. I now shoot a 17 Rem.