If you are regularly going to be faced with shots of 300 yds plus then you should probably check into the 22-250. If your shots are mostly going to be 300 or less the .223 will do everything you need it to do and do it just as well as the 250 and just as accurately. I like to carry a lite rifle for calling and shooting the .223 affords me the ability to see my kill shots in the scope because of minimal muzzle jump. Not critical, but a feature I like nonetheless.