I've got two Ruger single shots and here are my thoughts [hey that rhymes].
One of them is a box stock #1 in 22-250 with a 3-10 simmons 44mag on top. This rifle was my main coyote shootin' rig for several years. I never did much target work with it but I know it will go 10 out of 10 on steel chickens at 200 meters and it will kill a runnning coyote from 20 to 200 yards. the trigger is not what an after market Moyers (~$45.00 from Midway) unit could be but you can get used to it. With a cartridge sleve on the but stock follow-up shots are not a problem. It is a real kick to go out with a diehard semi-auto shooter and take a double with a singel shot right in front of their eyes (I supposes that makes me sound like an elitist snob, I'm not, ya gotta find fun where it can be found).
I've written about this rifle before. I got a hankerin' for a more fur friendly single shot and took one look at the price of a new #1 in 223. It scared me to death so I started lookin' around and found an old butchered #3 (a carbine version of the #1, mostly the same action with a different trigger housing/lever arangement, smaller forend and little more than a block of wood 10/22-mini14 style butt stock). The price was right so I bought it. Midway had CM Shilen barrels #5 contour, the 223 extractor was from Gun Parts Corp., the gunsnmith put in a nice tight stock 223 chamber and installed the barrel and a #1 site base rail, cut it to a handy 22" and put in a 10 degree target crown, I installed a Moyer trigger, and placed a 3-9 B&L Elite 3000 scope on top and did a bunch of stock work. Accuracy wise it will regularly break 4.5" balloons at 300 meters, thatsgood enough for me. This little coyote/fox/bobcat killer turned out better than expected and it is my Go-To weapon right now.
I have several other predator rifles but the Ruger Singleshots are my very favorite field guns.