Never have used either of these. How do they meter ? Are they stick or ball powders .My Sierra books list lots of loads for 22-250 for the RE 15. I am also loading for 223 bolt gun .The heaviest bullets in 22-250 i would use are some 65 Grn SBT however most bullets are going to be 50-55 Grn. I have been using H 380 but would like to get a possible alternative ,because of the temp sense talk on here though I have not really had issues so far.I do not like like weighing all charges so that is a prime issue for me .Used to burn 4064 and had many messes to clean up because of the bridges !