I just bought a Savage Model 10 Predator Hunter Max 1 in 22-250 and that thing will shoot, but if you really want a versatile varmint gun, consider the good 'ol 243 Winchester. My Tikka 1 in 10 twist in 243 can shoot 55 Noslers or 70's or the 95gr plastic tip hunting bullets, all sub-MOA. 55's doing 3800+ to 95's right there around 2,900 or 3,000 fps. That's a wide range of 'varmint' potential, all with better performance in wind -- but not necessarily very fur friendly.