I'd like to think I was a better shot than Kirsch, but it ain't happening. I do think one reason I have decent success with the 50 v-max is that I'm not pushing them as hard with a 16" barrel so I get a bit more penetration than would happen with a 22-250 around 3,800-3,900 fps. Here is a video I shot several years ago using the same load, same rifle, but unsurpressed. Range about 95 yds. This was a big male coyote.
I've had people say to me looking at this video, well that can happen when you can choose your shot on a bait pile, but calling you don't have the option for a perfect shot. And that's absolutely true, but it doesn't change the fact that if the bullet goes where it is supposed to they look like they've been run over by a train.