I have used both & could be happy with either, predators & up to deer & such. Many seem to think the Hornady is a firmer bullet, could be. I get a lot of pass-thrus with most everything, going with that soft tissue shot at back edge of the leg. I'm still shooting 165 grn interlocks I loaded up for the 308 years ago.
No, for bear I loaded up a 180grn partition, though the others would of done the job fine. I shot an average bear, not the 500lb'er.