In the last 2 years ive shot a 9 point 202 pound buck, and a 8 point 206 pound buck BOTH with a .243 using 95gr SST over 4064. Both ran about 15 yards then piled up dead on the spot. My Sister recieved a cow moose permit last year, and used my .243 loaded with Barnes 85gr ttsx over imr4064, and it was DRT. Her facebook page has the video as well=) ALSO there is a huge following of the .243 win in our black bear community, due to the low recoil during tree stand use. Im typicly not one to make "matter of fact" statements, but anyone who claims the .243 is handycaped for NA game, has either A. Never used one, or B. is simply a poor shot. As for Coyotes, I have found that the 62gr varmint grenade over, you guessed it, imr4064 has produced dime sized entry holes with no exit. All yotes are DRT. Our bait spot is 150 yards from shooting location, So i cant say much ragarding sub 100 yard terminal balistics.