When I had a .22-250, (I have had three) I tried quite a few of the above mentioned. If your not into saving hides, any of the above will work, some better than others. If your into saving hides, try the 52 grn James Calhoon DHP. I had never lost or destroyed a coyote. The biggest exit if there was one to be found was no bigger than a quater. I loaded them up with Varget at 3600 fps. I now shoot the same bullet in my AR in the .223 with Varget @ 3200 fps and the 33 grn DHP out of my .204 with Benchmark @ 4020 fps. I have taken two coyotes this year, one @ 50 yards and one at 178 yards. I couldn't find the exit on the further one and it was DRT.