Linus pretty much said it all regarding the .243 & coyotes.
Even though I've always loved the Sierra's over the past 30 yrs., the advent of the Hornady VMax's have converted me over to them almost exclusively.
I use the 55gr. VMax's in my .22-250, .223, and my 15" .243 Encore, as well as some Sierra BlitzKings.
If you want a higher probability of less pass through shots, use the VMax's in a lighter weight. Last year, my main hunting partner, who used a Sierra match bullet of, I think 87grs., in his .243 (against my recommendations), made a beautiful shot on a male coyote at 120yds. The shot caught the dog in the chest and angled back exiting from it's stomach area on the opposing side. The dog ran 150yds. with half of it's innards hangin out, and when I tracked it to it's location, the exit hole was massive.
Yep, I know....no match bullets, but the same thing happened to him the previous year using softpoints...almost identical, but the dog didn't travel as far.
I converted him to VMax's, or Nosler BT's, the same I use, and he hasn't had a pass through yet. The dog's hit go down in a pile...right now.
In my .22-250 I've had head shots on fox and chucks beyond 200yds. with no exits. My first coyote with them, up near Batavia, NY, resulted in a 210yd. shot, hitting the dog slightly above center on his chest, with no exit. The dog went down without a twitch, and his chest was turned to jello.
The load I have in my .243 is a 55gr. Sierra BlitzKing, over 43.0grs. of Varget and a Federal 210Match primer. Out of a rifle, this load would be somewhere around 3800fps. or so. That being said though, I've seen where the Sierra BK's were more sensitive to velocity than the Vmax's, and with a little too much speed, they start to come unglued.
Take care,
Bob