I have been using Barnes bullets for several years, and have had great success. I have used 300gr TSX, and 270gr TSX in my 375 H&H, on moose, and caribou. I use a 140gr in my 7MM, and a 62gr in my 243 Win.
The 300gr, and 270gr TSX in 375 H&H have been simply devastating on moose. One shot kills on two bulls, with a step, or should I say stagger. Both had large exit wounds, I added an insurance shot to a one big bull, but he was dead on his feet, literally. Bullets broke ribs entering,and exiting.
Caribou shot was complete pass through, and I hate to say the first shot was low, but shattered both femurs, and exited, second shot quartered from neck thru chest and was recovered against the far skin, completely intact. I had to shoot from 225 yds without a solid rest, and attempted the second shot quickly. Needless to say I did not thread it through the antlers like I wanted. Upon inspection, I had smashed through an antler, entered the neck, quartered across the chest, broke the far shoulder, and lodged in the skin. The bullet was intact, and had only lost it's petals. I'm not proud of that shooting, but the TSX "anchored" that caribou after smashing two major bones. Many other bullets would have come apart.
I took an antelope with a 140gr X bullet, before the TSX line, and with one shot at 75yds, lifted the buck off his feet, and dropped him with complete exit.
Have not hunted with the 243, but get .5 MOA with the 62gr TSX. The accuracy in all the calibers is at least MOA, or better with the Barnes X, or TSX.
I might sound sold on Barnes, and I am, but not due to anything but success. I have confidence that the Barnes bullets will "anchor" whatever game I pursue, and that is why I use them.