I debated for a while on what to build. I ended up building a 6x45.
Cheaper brass, don't have to worry about trying to find it after I shoot in the field.
Cheaper bullets, all 6mm are cheaper then 6.5mm
No special magazines needed, pmags work great.
No special bolt to buy, uses the same as 223
Easy reloading, not hard to find loads for.
I have yet to kill a deer with it, it is kinda border line on deer but I bet it'd work fine on a doe.
Love my 6x45, still cheap to shoot and packs more of a punch for coyotes.
Yeah a 6.5 will have more energy and less wind drift for long range but is it worth the extra $$?
It would be nice to carry around an Ar with enough energy to knock a deer down with no worries, if that's what your leaning more towards then I'd get the grendel.
And if you're gonna shoot 500 yards very regularly then the 6.5 grendel would probably be your best bet in an Ar platform.