We hunted Mexico for 12years. A gun permit with two guns were allowed for a cost of about $350. Each gun was allowed no more than 50 rounds of ammo. Always having a shotgun, the one rifle in the truck got used hard. We would try different caliber gun about every other year. I would load 25 of each type of bullet that I wanted to try with a total of two different bullet types. We would always shoot 25 animals straight of the same bullet style due to impact distances and angles.
In the 22/250's, we had great luck with the Sierra 53g Match, 55g SPT, 55g BTHP, and 55g NOsler BT with the speeds of each one in the 3550-3650 fps area. I had a 22/250 AI one year that we shot the 55g Nosler BT and the Sierra 55g BTHP, all with great success. NO doubt that the 22/250AI puts dogs down harder with the 55's at 4000 fps+. The Speer 52's blew up on shoulder blades out of the regular 22/250 and once in a while on a rib, concusion knocked the yotes out, they would get up drunk and staggering. We learned not to aim on a shoulder with the Speer 52g HP.
In the 243's and 6mm Rem's that I took down, we shot the 60g Sierra HP, the Sierra 75g HP, Sierra 80g Single Shot pistol bullet, 85g BTHP, and the 85g SPT. Sometimes Both 85's would shoot holes straight through yotes on a rare occasion. The Speer 75g HP shot at 3500-3600 blew up on shoulder bladess and hip joints.
We hid ammo in the truck for one and two week trips, lucky we never got caught.
Some 3 day trips would yield 50+ animals, week trips may go 100+ depending on how much fishing and bird hunting we did.
Worst 3 day trip we had was 13 animals, worst 1 week trip we had was 37...love bullet testing.
A lot of to doo has been made over bullet types. I really believe that you should concentrate on what kind of bullet your rifle will shoot the most accurate to give you the most confidence, and no matter what the caliber, place your shot.
Several years ago, I did some bullet testing for PMC ammo company on ground squirrels and jack rabbits. The ballistic's lab loaded us 250 of the NOsler BT, 250 of the Sierra Blitz king, and 250 of the HOrnady V Max...bless their Hearts! We shot 250 straight of each kind, and video'd much of each. NOsler was the toughest, Hornady second, and the hands down winner was the Blitz king...no contest....hence that is what they loaded in their 22/250 and 223 Ammo. Blitz king was so explosive, I have often wondered how the 55 would be on yotes. I have a great supply of the Nosler 55's, I doubt if I will ever try the Sierra 55 Blitz kings on yotes.
Coyotes are much different than ground squirrels and jacks. Often a coyote will have to be shot as he runs away, meaning that the bullet will have to break hips, spine, and travel a ways through the guts to get to the heart/lungs. A little tougher bullet in this shot works better. While these shots only occur perhaps 15% of the time, they are usually on a second or third coyote that comes in and buggs out. On broadside shots, about any bullet will work as long as the 22/250 are NOT behind the diaphram. When the 22/250 shots are behind the diaphram at distances of 150 yds or more, the yote may run off or get knocked down and get back up when your attention is on trying to get another yote on that particular stand. No doubt that the 55g Nosler BT is the tougher of the poly tip bullets with it's extra thick base, and the jacket at the base is also thicker.
A hunting partner's team got 17 on one stand in Mexico, and our all time best stand was 13. I can distinctly remember one stand where we had 7 on the ground at one time, with two coyotes that had re-gained their feet attempting to hobble off, and a third attempting to get up. Those yotes had been shot with the Speer 52's with a muzzle velocity of 3550. We shot 11 rounds on that stand alone...I was upset that I had only brought down a box of 50. We had to ration our shots the rest of the trip, and crossed the border back into the USA with 3 bullets left.
I can see clearly in my "mind's eye", several coyotes hit broadside at 65-75 yards with a 243 using the Hornady 75g HP at 3600 fps. They spun around and ran off with blood spots on their off side the size of a saucer, we never found them and on a competitive hunt, that was a real bummer. The Sierra 85g Spt and the 85g BTHP are...tough. We would loose 2-3 out of a 100 with them failing to open up at distances 150 yds+ with good center body hits. There is simply no explaining why a bullet fails to open up...could be the guilding metal used on that lot# of bullets, could be the lead/antimony mix in the lead core...who knows. I know that there is a difference in lot to lot variations on some bullets as bullet makers use what the foundry gives them on jacket material and lead/antimony core mix.
In grading the 55's out of a 22/250 at 3550-3650, I would put the Sierra 55g spt and BTHP at the top, with the 55g Nosler BT close behind. I have never shot the Hornady's on yotes, so I can't give you an opinion on them. The Sierra 50g Spt also gave us great results out of a 22/250 shot at 3800+...big holes...big holes...mangled up yotes.
The biggest mess that we ever saw made of yotes with a 22 Caliber was with the Sierra 55g Blitz lead tip at 3550, looks like you planted a bomb up the butt of a yote. This bullet absolutely grenades a yote, but I would not attempt to shoot this bullet in anything other than a 1-14 twist 223 or 22/250 and limit velocity at a max of 3550 in anything other than the best of the custom barrels.
One thing that we learned over and over, 22 and 6mm bullets do not shoot well through bushes and tall grass, with the lead tip bullets and HP doing MUCH better in circumstances of tall grass. Poly tip bullets never make it through tall grass...just pass on the shot.
What ever you do, have confidence in your gun or practice till you do. If you see that you are getting spinners, try another bullet after you have checked for poor bullet placement. Bullet style will not make up for a poor shot too far back behind the diaphram on 22's while 243's and 6mm Rem's are another story.
Good luck with your bullet choices!