Years ago, I had a 257 Weatherby with zero freebore in a 10T Pac Nor super match barrel, 26" length.
100g ballistic tips at 3850 really made the hair fly on a coyote. 87g speer at 4130 detonated coyotes. Don't discount the speer 100g btsp. Barrels will like what they like, and I have had spectacular success out of the 100g speer btsp when the barrel preferred it over the ballistic tip. Deer, coyotes, rock chucks, jack rabbits all died humanely.
I think that your 25/300 will equal the 257 weatherby.
Good luck