Yep, I'll take a 25-06 over a 243 for a true dual purpose coyote/deer rifle for longer ranges. The extra velocity and energy do make a difference. If your not shooting much past 300 yards, you probly dont need the 25-06, but its still better for deer.
I've had both and I think the 2 both have there place. The 243 is great with light fast bullets, shoots like a laser as stated. Its a great coyote round IMO, but the 100g bullet at 3100fps is a little lacking for deer at the ranges I regularly shoot at. That is where the 25-06 with 200-300fps gain in speed comes in with the 100g bullet, or bump up to a 115g at 3200fps and its no contest as to whats better for deer. I've long used the 115g nbt at 3200fps to take coyotes, deer and black bears out to 600 yards with no problems. Most were DRT and the very few that weren't only went 20-30 yards. Never recovered a 115g nbt from anything. I've used the 75g vmax at 3800fps and 85g nbt at 3700fps for a while on coyotes, also the 100g nbt at 3350 for coyotes/deer. Have tried them all from 75's to 85's, 90's 100's, 110's, 115's, 117's, 120's, 125's, with virtually every powder from IMR4895-Retumbo. Am now liking my new found load with Retumbo and 100g NBT's. I am getting right at 3500fps and 1/2 MOA out to 400 yards from a 24"shilen barreled 700. That load will be hel on coyotes, (dont care for the hide anyways) and will be equally as good on deer from 200-600 yards. My last 5 shot group at 620 yards was 5", with 4 of them going into 2".
If you plan on shooting some distance and want the thump to back it up and put them DRT, just get the 25-06 and never look back.