I'm with midwestpredator, I'd go with a heavier bullet & mostly accept the pass-thru. The simple solution is to load an acceptable deer bullet & use that if you take the 243 on a deer hunt. A good choice then would be an 85 grn Gameking from Sierra.
I've shot a few coyotes with that bullet & damage is surprisingly limited. Yes, there are variations, depending on placement & all.