I have shot 4 whitetail does with my 25 DTi predator load just recently and none have gone more than 20 yards and two dropped in their tracks. The load is 28.7gr of N133 with the 85gr Nosler BT. Speed is right at 2900fps and it is a good load for knocking down coyotes but I have gotten almost all pass-thru's on broadside hits. Bobcats have had quarter sized exits and fox... not too pretty.
"Anyone taking up handloading necessarily plays with unknown factors and takes chances. But so does anyone who drives a car,goes to a cocktail party,eats in a restaurant,or gets married."

Jack O'Connor 1963