Just my 2......
If you're going to shoot the lighter more frangible polymer tipped bullets in your .243's, and you load your own, you'll have to drop the speed a little.
Pushing them too fast, especially at closer ranges, won't allow the bullet ample "time in target" to perform it's magic.
Sounds odd, yes, I know, but even the most frangible bullet will pass right through an animal if shot at too close a distance, and/or at such a higher velocity.
Slowing the load down to 3500-3700fps, will bring the bullet's performance into it's "sweet spot" as far as ranges and performance go.
Most .243's loaded with standard weight bullets, and of regular construction, will most often, pass right through a coyote, causing moderate internal damage.
Using the VMax, Nosler BT's and the Sierra BK's, at slightly reduced velocities, will usually allow the bullet's fragile construction, time to detonate inside the coyote and drop them on the spot.
As an example, I'm using a load of 43.0grs of Varget in my 15" .243 Encore, loaded under a 55gr. Sierra BlitzKing.
The load is doing 3550fps. over my chronograph in that handgun length barrel.
I've nailed several fox, chucks and animals somewhat lighter than the coyote, at average ranges from 150-250yds.
I've had one pass through on a chuck at the shorter range, just once.
The bullet just "jell's" the critters shot with it, and based on these field tests, I'm assuming that on the coyote, it would be just about perfect.
Something too close in, with just about anything worthy of nailing coyotes, might pass through. Frangible bullet or not.
Just a thought.......
Take care,
Bob