just for clarification - the main reason folks are saying 150yds and under for the cartridge, aside from wind drift, is based on its MV and the terminal performance designs of the vmax bullets the cartridge primarily uses.
vmax are only engineered to expand dramatically at >1600 fps. the closer you get to there, the less... spectacular... the impact result is.
based on the MV and BC of a typical rifle/bullet combo for the HMR, somewhere just shy of 150 yds is when the bullet falls below that velocity threshold, therefore often turning it into the proverbial ice-pick, barring it doesnt make contact with something relatively substantial (bone) during its travels thru the furcoated meat sacks we're throwing it at.
at 100-125 yds... impacts are usually spectacularly impressive. at 150-175... usually quite lackluster on the terminal performance department.
HTH!