Ive done by far the most shooting and loading and have the most data for the 25-06 then any other cartridge. Its my favorite cartridge by far. I've had 4 of them in the last 10 years and have probly put over somewhere between 5-7 thousand rounds downrange with them.
If I was limited to 3 powders in the 25-06, it would be IMR4350 for the lighter to medium weight bullets, RL22 for the medium to heavies, and Retumbo for the heavies.
My last 25-06 was a 24" shilen barreled 700 and was a flat out shooter, it smoked em out there as well, right on heels of factory 257 WM...
My last one (24" shilen barreled 700) did 3900fps with 75g vmaxes, 3500fps with 100g NBT's, and 3275fps with 115g NBT/VLDs, these were upper end loads that still shot very well, 1/2 MOA at 100 anyways. IMR4350 was used for the 75g vmaxes and Retumbo was used for the 100g and 115g pills. Should not have sold that rifle...Stupid, stupid me...
Retumbo is a lot better then Rl22 far as consistency from lot to lot and temp sensitive is not even close, thats why I started working with Retumbo in the 25-06. Rl22 just gives to much headache unless you buy it in kegs...