Well, the first thing that I do is bed the rifle, float the barrel, adjust the trigger, mount scope.
Then I clean the barrel, brush with JB unless it is a custom barrel, in which case, I would just push patches down the barrel.
Next, I establish the seating depth with the various bullets that I want to try, touching the lands with the bullet is preferable.
I bore sight the rifle using an unfired case with no primer in the case, looking though the flash hole of the case.
I don't give a hoot in hades how well the powder fills the case. Check the Nosler manual to see their most accurate loads with various powders and start loading. Also, cross reference a site:
http://www.centerfirecentral.com/ to see how fellows with your exact same rifle shot with various bullets and loads (check anything you read on this site against a reloading manual in case the poster had a typo on his load).
After working up a load at 100 yds, I try the load at 200, 300 yards to see if it has "fell apart".
Most of your success comes before you ever fire the first round, in accurizing, checking seating depth, and doing your research in the Nosler manual and on the Centerfire central site.
Everybody is different, it's just a hobby, make it fun your way.