FWIW, loaded up some IMR4166 Enduron with Nosler 70 grain bullets for my 6x45 rifle a couple of days ago. Meant to shoot them today, but didn't. However, I have had some decent results for accuracy with the IMR4166 in my reloads for the .223 and .308. Haven't used the powder much....kinda pricey compared to other powders I normally prefer.