Several things to consider. I shoot a lot of lead tips, hp,and poly tip bullets.
I noticed when shooting yotes that the HP usually penetrated deeper, meaning that they would not blow up on a shoulder blade or a hip joint.
I shot thousands of the poly tip bullets on p. dogs and they skip across the prarie just like the HP do, so forget the whole notion that they blow up on impact. Maybe the 40's do at unreal velocities, but I do not shoot the 40's except on test loads.
There is one more major consideration, that has it's + and negative points. The sharp Poly tip bullets have their ogive's pushed way back on them, unlike most of the HP bullets (it is difficult to lump all the HP bullets as being exactly alike). With the ogive being pushed back and having less bearing surface, the bullet may have to jump further to reach the lands. At some point, the bullet gets started crooked, meaning less accuracy. Many of the HP designs are not as aerodynamic, but they have the ogive further out on the body of the bullet, meaning they would be jumping less if both bullets were seated to the same Over all length. Guns that shoot short magazine, such as the AR-15 platform, Cz, and the Rem 788 may indeed find that a less pointed bullet be more accurate or even one of Sierra's fine Semi Point bullets, 50,55, or 63g bullets.