Salmo22, I shot p. dogs with 5 different 22 PPC's, they are very accurate. Cost of brass is prohibitive, so I started making the brass out of 7.62x39 PMC brass that worked out very well, brass is tough as Lapua brass if not tougher. I shot the 50s out of the 22 PPC at 3575 and the 55's at 3500 using a ball powder WC844 that is unreal accurate and gives much better barrel life over N-133 and H-322. WC844 gave it's best accuracy node in the 3550 fps area with 50g Sierra Blitz, with accuracy in the high 1's and low 2's. WC844 is still available for about $99 per 8 lbs.
Now a different spin on things. You could accomplish the same thing by going with a minimum spec Match chamber in a 26" 223 with zero freebore and .2245 throat. You would not give up .035 in accuracy over the 22 PPC with a huge cost reduction in brass. I shoot IMI brass in my custom 223 with amazing accuracy, really good enough to shoot a regisgtered BR match with and place middle of the pack with 50 & 55g Nosler Ballistic tips.
The Sierra 52 and 53g Match Hp's are not worth a hoot on p. dogs, Bergers are a little better. The Sierra Blitz kings are the most explosive in my opinion on ground squirrels and p. dogs.