I recently worked up a load with the 55g CT in a VSSF 22/250. The load was 41.5g of Win 760, Win primer, Rem case, bullet seated to touch the lands, at 3830 fps...very fast for a 22/250. This load is usually hot in a non coated bullet, the coating must reduce the friction/pressure on the load or this barrel just likes a hot load. This load shot in the .300 range at 100 yards and shot 1 1/2" at 400 yards with a Burris Black Diamond 8-32 scope.
As to how this bullet kills predators...I can not comment. I have shot quite a few yotes with the 55g Nosler with extremely good luck out of a 22/250 AI...with no bullet failures on ribs or shoulders...that solid base just keeps on trucking!