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Concerning Varget and the .45-70... I don't know about anyone else, when I was working up loads with the 350 gr. Hornady flatpoint, Varget spiked in pressure very, very, quickly. I was able to get excellent accuracy, but nowhere near max velocities with Varget. The difference between no pressure signs and wild erratic pressure was about 1 grain of Varget in my rifle. I don't know, maybe my 1974 Marlin M1895 has a really tight chamber, but every other powder seems normal in this rifle and I've tried RE-7, IMR-3031, IMR-4198, and H4198 besides the Varget. I would caution working up very carefully with Varget and maintaining good loading discipline when loading cartridges. A little mistake could mean a lot if it behaves in anyone elses rifle like it did in mine. I've used Varget in .243 and .308 with no such problems... /ubbthreads/images/graemlins/confused1.gif
I've used both of the 4198's with good success. The Hornady 350's (flat and round) are good bullets. I've put the 350RN on top of a decent load of H4198 and called it my "headache round". If you do use this combo you really need to have a chrony (me, not yet) for approaching max loads. There is a sizeable discrepancy in listed data with Hodgdon showing a significant amount higher than other data. When talking to a gunsmith in a local shop he couldn't believe the difference in H4198 and IMR4198 listings. I've gone as high as 54gr with the H4198 @60gr listed max (depending, of course on whose listing you read).
I'm currently using the H.