I have not shot any 'yotes with the Amax. However, I have shot quite a few woodchucks, and a couple whitetails with the 75Amax out of a 22-250. The Amax works perfectly fine on the 'chucks, not as explosive as the Vmax though. I have to agree with the above post, I would take a CNS poke with one, but would try my hardest to stay away from bone. Now on wt's it was a friggin' grenade in my experiences. I shot 2 with them last year, farther one was 250yds. It worked and I got a bang-flop but hardly any penetration. I would not use the Amax on a deer sized critter again, at least in the 22-250. There are much better choices in deer bullets but I had to try it for myself.