Without question the .22-250 is the superior caliber for the range you are looking to be shooting.It is a very flat shooting caliber with alot of punch.The .222 is great for 100 to 175 yards but for much past that go with guns such as the .22-250,.220 swift,.243,or 6mm.Not to mention the ackley improved calibers too.Hope that helps.GOOD HUNTING