Derby hit the nail on the head. I have been shooting a 22-250 in CA for 11 seasons now. The lead free changeover took a lot of time and effort. My rifle, 1:12 twist shot the Barnes ok but I didn't really like how they fouled the barrel and their accuracy. After a lot of handload trial and error I am happy with the 40grn Nosler ballistic tip lead free at 4,150fps under CFE223 powder, it anchors them. If you don't handload the lead free thing can kind of be a pain and expensive. If I was starting again I would just get a 223 and shoot the 50grn Nosler ballistic tip lead free or a 243 and shoot the 55grn NBT LF. Or one of the new 1:10 twist 22-250's I suppose. My son's first season is this year and he shoots a 223 with 50grn NBT LF and I don't feel he is undergunned one bit. Just be real careful with those Barnes, I shoot the 80grn in my 25-06 and I am VERY particular about what stands I use it on, a coyote won't even slow one of those things down.
Don't be fooled by the San Diego urban interface coyotes, things get a little more tricky when you get out on public land.