I may not be vetted on here as far as harvest counts, and thats fine. I will not claim to not have had predators run off or not be anchored, because will happen, no matter the caliber, no matter the distance, I'm convinced of that. I've witnessed yotes try to run, and make it 80+yrds, with no brisket, no ability to control their front legs... yes...they ran on their hind legs... We have tried many different shotgun loads, starting with all your fancy T shot and BB's and tungsten this and that. As well as all different leads from different manufactures. REMINGTON, #4 BUCK, 3", NOT 3 1/2", 3" is the most lethal, with any choke,standard 3-4 that come with interchangeable, to fixed old and new modified/fulls, to just about everything threaded for Benelli/Berretta,turkey this/that full, extra, improved, etc, load to 70yrds. Now for .224... .223/.22-250, bolts and autos, factory, and many, many handloads....55 G NOSLER BALLISTIC TIP. Not 60, 69, 50, 45, ...55GRAIN! Second to 55 G Sierra Blitzking. I feel that we have thoroughly tested all available to us, and there will never be a replacement for shot placement as well as presentable shot for placement. These are the hammers as we know it. I feel Remington will replace that buck load with something different. Stock up!