I want to use the bullet that is best suited for the larger predators and hogs . My 22-250 is 24 in factory Rem barrel and I think is 1 in 12 twist. The Sierra book list the heaviest Game King as 55 Gr # 1365 & # 1390. I think the heavier ones are not suitable for my rifle .I have not tried the above bullets yet but I do have both on hand .If they group similar which would be the tougher of the two for penetration .Mainly for Coyotes but there is a good number of Wolves in my area.If you have experience with these bullets I would love to hear about it !