I have two, nearly, identical CZ 527 Varmint model 17 Hornets with the only difference being one of them I had the barrel cut back to right around 20.5-21 inches when it was in getting threaded and the other one is a little over 23 inches. The shorter one only shoots 50-60 FPS slower than the longer one, which isn't much difference.
With the 22 Hornet shooting so little powder, and the fact you have a larger bore diameter, I'd imagine the gap between the two would be even less. A suppressed 22 Hornet with anything from a 18-21 inch barrel + suppressor should make for a pretty fun and very maneuverable setup.