I agree 600 is about the max of the round. (for a normal factory rifle) I load 60gr V-max's in my Savage 22-250 (1 in 12 twist) and longest I have been able to shoot is 300 and I can consistently blow up 20oz bottles. It all depends like the other posts have said depends on your rifle, scope, shooting rest, weather, ammo. But I would say with the right variables you can take a 22-250 out to 600 yards.