Bruce Hodgdon named the powder after his favorite load for the 22-250, 38 gr and a 52 gr bullet...hence H380.
I've never had any "temperature sensitivity" issues with it except at low temps, but like most ball powders it gets a bit testy when you push it. Varget is better at low temps [beeep]'. It burns cooler than log or flake powders, I've used it in several 22-250's and 220 Swifts and othe small and medium sized cases.
I try it and other powders in the same burn rate when I'm working up loads and use whatever powder gives me the best accuracy.
Newer powders do have much better burn characteristics and I'm slowly converting as I use up old stocks of powders...4007, 8208, RL-15 and 17, Varget all are getting the node over some of my old "standbys".
Luck