Any of the 3 will work well,if used inside of their ranges! The 243 has the edge,if it's a shot a longer range,and in windy conditions,by using a heavier bullet. Sometimes when we are calling coyotes in small areas (where the shots are 175yds. and less) we use a 22 Hornet!( how's that for opening another can of worms?) It's a matter of the right tool for the right job at hand. Simple enough! Ron