I normally use my 30-06 but I wanted to maybe get the 22-250 bloodied up on the deer population. I use Hornady 55gr vmax factory ammo. With the deer being smaller on average down here in South Georgia than the North I'm thinking that it might work ok. I just don't want to injure something using too small of a gun.
Some folks who use the V-Max have had problems with surface splash on coyotes. Can't imagine using them on deer. That is a varmint bullet, not designed for big game.
Personally, I'd use a heavier bullet with a sturdier construction design, with the Nosler 60gr Partition being at the top of my picks.