I have owned five 22-250's, and all five loved Winchester brass, Federal 210 GM primers, 55 grain Ballistic Tips, and 39.0 grains of W-760. That clocks about 3550 out of a 26" barrel. It burns clean and cases last forever. I like how ball powder meters when I sit down to load a few hundred rounds. I won't talk about group sizes, as we shooters tend to be a skeptical lot (and rightly so, considering the stories a guy hears). Let's just say that I was willing to spend some money on components to get the load I wanted. I spent some money, but I got my load, and she's a beauty. I will admit that this is a very old school load, and I have heard nothing but praise for Varget. 22-250's are not known to be finicky, so you shouldn't have to sit at the bench too long to get something you like. Good luck