454 Puma, It is physically impossible for the .223/5.56 to propel a bullet of the same weight, at, or over the velocity of the bullet fired from the 6 x 45 at the same pressure.
The .223/5.56 VS. the 6 X 45 is not unique in this situation. Anytime you take a given case, with the same pressure and increase the bore diameter, you are going to get more energy out of the larger bore. The .243 Win. VS. .308 Win. .243 WSSM VS. .25 WSSM. Any of them that you can come up with to compare will give you the same results: The larger bore will give you more energy.
The reason of this is quite simple. It is the volume occupied by the base of the bullet, VS. the same amount of pressure acting on it. The limiting factor on a case is the maximum pressure. Exert that same pressure on a larger area, and you will do more work, or get more energy.
The base of a .243 bullet is about .3817 square inches. The .224 bullet is about .3518 square inches. Apply the same amount of pressure to both of these areas and you will get more energy out of the one with the larger area occupied. You can dispute it all you want, but it is a mathematical certainty.