I killed many, many yotes in Mexico with the 60g Sierra, 48g of Win 760 with a fed 210 primer, accuracy is less than 1/2" in one of my current Rem 700's with a 9 1/4" twist.
Win 760, H414, and AA2700 has proven to be excellent preformers with the 55g-62g bullet weights in the 243's.
Velocity was in the 3800 area in my rifles. I sighted in at 200, aimed at the top of their backs to 300...hard to beat. Other powders do not produce the velocity that 760 does, when the bullet is shot at 3650, it drops like a rock after 300.
Good luck!