Bman, I shot the Nosler 60g HP and the Sierra 60g HP years ago on yotes, they both shot holes through yotes in a Rem 700 Varmint, 1-14 twist.
Your hornady be a different animal, hope so.
Both the sierra and Nosler 60g HP loved a load of 39.0g of IMR 4350 with a Win Primer, bullet seated to touch the lands.
Let us know how they do on yotes