I have three 22 Hornets that I feed regularly.
Like any centerfire rifle, you'll have to do some testing to find the best load for your rifle.
I began my reloading in 1948 for a 22 Hornet, and have had at least one for the intervening years.
I think there are some special things that are worth trying to get best accuracy from a Hornet. I now use small pistol primers, and crimp bullets after seating them. Outside of those two things, everything else is the same as loading for other CF rifles.
My rifles like 10.2 grains of H-110, and/or, 13.0 grains of Lil-Gun powders.
Bullets that work now, and 60 years ago, are the Sierra 45 grain Hornet bullets. Others that shoot well are the 40, and 45 grain Starke bullets, and the 40 grain Blitz, with either of the powder charges mentioned above. Quite possibly, the Hornady, Nosler, and Speer 40 and 45 grain bullets will shoot best in your rifle. Some get good accuracy with the Calhoun bullets, however, they don't shoot well for me. But, that's a rifle thing, and your rifle will tell you what it likes, not the other way around.